Research Interests
Developmental and experimental psychopathology of schizophrenia and related disorders
- Trajectories of psychotic-like experiences or specific traits for psychosis
- Negative symptoms and functioning
- Self impairments
- Emotional and motivational dysregulation
- Neurocognitive and underlying brain structure and functional impairments
Early identification of high risk individual prone for psychosis
- Endophenotypes approach
- Gene-brain mapping approach
- Developmental trajectories of neurocognitive, emotional and psychosocial functioning
Neurocognition and social cognition evaluation and intervention
- Prospective memory and working memory
- Emotional and social interactive functioning
- Empathy, Theory of mind, and perspective taking
Methodological Approaches
Endophenotypes
- Identifiable sets on cool and hot components
Behavioural
- Self- and informant-reported checklists
- Computer and neuropsychological tests
- Neurophysiological data: Biopac measures
ERP
- Comparing ERP paradigms
Neuroimaging
- Structural connectivity: DTI
- Functional connectivity: Resting-state and fMRI
- Intervention: Real-time imaging
Gene-Brain Mapping
- Genetic association and/or GWAS
Across species paradigms
Wang X., Yu, J. T., Wang, L. L., Huang, J., Wang, Y., Lui, S. S. Y., Chan, R. C. K.* (2025) Cerebellar stimulation modulates reward processing: A high-definition transcranial direct current stimulation study. Cerebellum. 24: 153, https://doi.org/10.1007/s12311-025-01902-2
Current work
Recent work in NACN lab has extended to a transdiagnostic approach to mental disorders, particularly focusing on the important role of the cerebellum and its related neuroanatomical and functional connectivity contributing to the development of psychopathologies and neurocognitive impairments in neurodevelopmental and neurodegenerative disorders.
Join Us in Research
The NACN Lab invites researchers, academic institutions and research project participants to join us in advancing our understanding of neuropsychiatric disorders. Together, we can explore innovative solutions and groundbreaking research.